Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

  title={Leukotriene C: a slow-reacting substance from murine mastocytoma cells.},
  author={Robert C. Murphy and Sten Hammarstr{\"o}m and Bengt Samuelsson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={76 9},
Murine mastocytoma cells treated with calcium ionophore A23187 produced a slow-reacting substance (SRS) that caused guinea pig ileum to contract. The response was reversed by the SRS antagonist FPL 55712. On the basis of isotope incorporation experiments, spectroscopy, and chemical degradations, the SRS was identified as a cysteine-containing derivative of 5-hydroxy-7,9,11,14-icosatetraenoic acid. This amino acid was attached in thioether linkage at C-6. The SRS is structurally related to… CONTINUE READING

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