Leukotriene B4 receptor 1 expression on dendritic cells is required for the development of Th2 responses and allergen-induced airway hyperresponsiveness.

@article{Miyahara2008LeukotrieneBR,
  title={Leukotriene B4 receptor 1 expression on dendritic cells is required for the development of Th2 responses and allergen-induced airway hyperresponsiveness.},
  author={Nobuaki Miyahara and Hiroshi Ohnishi and Hiroyuki Matsuda and Satoko Miyahara and Katsuyuki Takeda and Toshiyuki Koya and Shigeki Matsubara and Masakazu Okamoto and Azzeddine Dakhama and Bodduluri Haribabu and Erwin W. Gelfand},
  journal={Journal of immunology},
  year={2008},
  volume={181 2},
  pages={1170-8}
}
Dendritic cells (DC) are important APCs that control allergen-induced airway responses by interacting directly with T cells. Leukotriene B(4) (LTB(4)), interacting with its high-affinity receptor, LTB(4) receptor 1 (BLT1), is known to attract and activate leukocytes during inflammation. We have previously shown that BLT1 expression on Ag-primed T cells is required for the development of airway hyperresponsiveness (AHR; Miyahara et al. 2005. Am. J. Respir. Crit. Care Med. 172: 161-167). However… CONTINUE READING

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