Leukotriene B4 production in human mononuclear phagocytes is modulated by interleukin-4-induced 15-lipoxygenase.

@article{Profita2002LeukotrieneBP,
  title={Leukotriene B4 production in human mononuclear phagocytes is modulated by interleukin-4-induced 15-lipoxygenase.},
  author={Mirella Profita and Angelo Sala and Liboria Siena and Peter M Henson and Robert C. Murphy and Alessandra Patern{\'o} and Anna Bonanno and Loredana Riccobono and Angela Mirabella and Giovanni Bonsignore and Antonio Maurizio Vignola},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={300 3},
  pages={868-75}
}
The aim of this study was to evaluate the consequences of interleukin (IL)-4-induced 15-lipoxygenase (15-LO) expression on leukotriene B4 (LTB4) synthesis in human monocytes. Human monocytes incubated for 24, 48, and 72 h with IL-4 (10 ng/ml) were stimulated with Ca2+-ionophore A23187 (calcimycin; 5 microM) or opsonized zymosan. 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE], LTB4, and arachidonic acid (AA) release were measured by high-performance liquid chromatography/radioimmunoassay… CONTINUE READING
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2000a) 15(S)-HETE release and reincorporation

  • M Profita, A Sala, +7 authors AM Vignola
  • 2000
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