Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis.

@article{Griffiths1995LeukotrieneBP,
  title={Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis.},
  author={Roberta J. Griffiths and E. R. Pettipher and Kay Ellen Koch and Craig A. Farrell and Ronald Breslow and Maryrose J Conklyn and Mark A. Smith and B C Hackman and D J Wimberly and A. Milici},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 2},
  pages={517-21}
}
Leukotriene B4 (LTB4) is a product of the 5-lipoxygenase pathway of arachidonic acid metabolism. LTB4 is a potent chemotactic factor for neutrophils and has been postulated to play an important role in a variety of pathological conditions including rheumatoid arthritis (RA), psoriasis, and inflammatory bowel disease. The role of LTB4 in such diseases has not yet been defined but in this paper we provide direct evidence that LTB4 plays a critical role in a murine model of RA. CP-105,696, (+)-1… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

Similar Papers

Loading similar papers…