Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6.

  title={Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6.},
  author={Johan Bylund and Adam G Harder and Kristopher G. Maier and Richard J. Roman and David R. Harder},
  journal={Archives of biochemistry and biophysics},
  volume={412 1},
Leukotriene B(4) (LTB(4)) is a lipid mediator that plays an important role in inflammation. Metabolism of LTB(4) by cytochrome P450 (CYP) enzymes belonging to the CYP4F subfamily is considered to be of importance for the regulation of inflammation. This study investigates LTB(4) metabolism by recombinant rat CYP4F5 and CYP4F6 expressed in a yeast system and by microsomes isolated from rat organs expressing CYP4F mRNA. CYP4F6 was found to convert LTB(4) into 19-hydoxy- and 18-hydroxy-LTB(4) with… CONTINUE READING

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