Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis

Abstract

INTRODUCTION Bone erosion in inflammatory arthritis depends on the recruitment and activation of bone resorbing cells, the osteoclasts. Interleukin-23 (IL-23) has been primarily implicated in mediating inflammatory bone loss via the differentiation of Th17 receptor activator of nuclear factor κB ligand (RANKL)-producing cells. In this article, we describe a… (More)
DOI: 10.1186/s13075-014-0496-y

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