Leukotriene A4 hydrolase is a zinc-containing aminopeptidase.

  title={Leukotriene A4 hydrolase is a zinc-containing aminopeptidase.},
  author={Mayumi Minami and Nobuko Ohishi and Hiroyuki Mutoh and Takashi Izumi and Haruhiko Bito and Hajime Wada and Yousuke Seyama and Hiroyuki Toh and Toshiyuki Shimizu},
  journal={Biochemical and biophysical research communications},
  volume={173 2},
A comparison of amino acid sequences revealed that leukotriene A4 (LTA4) hydrolase is homologous to various types of aminopeptidases. Consistently with the finding, the purified LTA4 hydrolases from both human and guinea pig sources contained equimolar zinc ion, as determined by atomic absorption spectrometry. The enzyme had a significant amount of aminopeptidase activity toward synthetic peptide substrates. Both LTA4 hydrolase and aminopeptidase activities were inhibited by o-phenanthroline, p… CONTINUE READING