Leukotriene A4 hydrolase: an anion activated peptidase.

  title={Leukotriene A4 hydrolase: an anion activated peptidase.},
  author={Anders Wetterholm and Jesper Z. Haeggstr{\"o}m},
  journal={Biochimica et biophysica acta},
  volume={1123 3},
The peptidase activity of leukotriene A4 hydrolase purified from human leukocytes has been characterized, utilizing synthetic amides as substrates. The enzyme was stimulated by several monovalent anions. Thiocyanate ions were most effective followed by chloride and bromide ions. In phosphate buffer alone the peptidase activity towards alanine-4-nitroanilide was barely detectable and addition of 100 mM NaCl increased the specific activity more than 20-fold. Increasing the concentration of NaCl… CONTINUE READING


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