Leukoencephalopathy following high-dose iv methotrexate chemotherapy with leucovorin rescue.

@article{Allen1980LeukoencephalopathyFH,
  title={Leukoencephalopathy following high-dose iv methotrexate chemotherapy with leucovorin rescue.},
  author={Jeffrey B. Allen and Gerald Rosen and Bipin M Mehta and B H Horten},
  journal={Cancer treatment reports},
  year={1980},
  volume={64 12},
  pages={1261-73}
}
Seven patients with bone or soft tissue sarcomas but without metastatic CNS disease developed a chronic leukoencephalopathy after high-dose (8000-15,000 mg/m2) iv methotrexate (MTX) chemotherapy with leucovorin (LV) rescue. Approximately 12 MTX-LV treatments were administered over a 3-7 month period. None of the patients had cranial irradiation. The syndrome usually began several months after the initiation of chemotherapy with subtle personality changes followed by a progressive dementia… CONTINUE READING

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