Leukoencephalopathy due to Oral Methotrexate

  title={Leukoencephalopathy due to Oral Methotrexate},
  author={In{\'e}s Gonz{\'a}lez-Suarez and Mar{\'i}a Jos{\'e} Aguilar-Amat and Miguel Trigueros and Alberto Borobia and Angy Cruz and Javier Arpa},
  journal={The Cerebellum},
Methotrexate (MTX) is considered the main agent for the treatment of rheumatoid arthritis (RA). Neurotoxicity is often mild, but severe encephalopathy can develop, especially with intrathecal or intravenous administration. In rare cases, this syndrome has been observed in patients on long-term low-dose oral administration. A 68-year-old male was diagnosed with RA and on treatment with oral MTX 25 mg weekly for 4 years. The patient started with progressive dysarthria, ataxia and cognitive… CONTINUE READING
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