Leukocytosis, JAK2V617F mutation, and hemostasis in myeloproliferative disorders.

  title={Leukocytosis, JAK2V617F mutation, and hemostasis in myeloproliferative disorders.},
  author={Marina R Marchetti and Anna Falanga},
  journal={Pathophysiology of haemostasis and thrombosis},
  volume={36 3-4},
Thrombosis is a leading cause of morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia vera (PV). Several mechanisms have been proposed to cause or to contribute to the acquired thrombophilic state of these patients, including platelet and red blood cell abnormalities. The increase in white blood cell count, found in most subjects with these disorders, raises the possibility that circulating leukocytes may represent another prothrombotic factor, as… CONTINUE READING
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