Leukocytes, cell adhesion molecules and ischemic acute renal failure.

  title={Leukocytes, cell adhesion molecules and ischemic acute renal failure.},
  author={Hamid Rabb and Y M O'Meara and Paola Maderna and Patrick Coleman and Hugh R. Brady},
  journal={Kidney international},
  volume={51 5},
Ischemic acute renal failure (ARF) is a common clinical syndrome, associated with high morbidity and mortality, for which there is no specific therapy. Polymorphonuclear neutrophils (PMN) recruited during reperfusion have been implicated as mediators of renal parenchymal injury in ischemic ARF. Leukocyte adhesion molecules appear to facilitate PMN recruitment in this setting. Complementary studies using monoclonal antibodies, antisense oligonucleotides and gene "knock-out" indicate that… CONTINUE READING


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