Leukocyte trafficking mediated by selectin-carbohydrate interactions.

  title={Leukocyte trafficking mediated by selectin-carbohydrate interactions.},
  author={Rodger P McEver and Kevin Lawrence Moore and Richard D. Cummings},
  journal={The Journal of biological chemistry},
  volume={270 19},
The selectins have attracted intense interest because of their carbohydrate-recognition properties and their pivotal roles in leukocyte trafficking. Future studies will center on the mechanisms for regulating the expression of the selectins and their ligands, the molecular details of selectin binding to glycoprotein ligands and small carbohydrates, and the biophysical principles that selectins employ to mediate attachment and rolling of leukocytes under flow.