Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells

@article{Smith2007LeukocytespecificP1,
  title={Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells},
  author={Alvin L. Smith and Lakshmanan Ganesh and Kwanyee Leung and Jenny Jongstra-Bilen and Jan Jongstra and Gary J. Nabel},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={421 - 430}
}
Dendritic cells (DCs) capture and internalize human immunodeficiency virus (HIV)-1 through C-type lectins, including DC-SIGN. These cells mediate efficient infection of T cells by concentrating the delivery of virus through the infectious synapse, a process dependent on the cytoplasmic domain of DC-SIGN. Here, we identify a cellular protein that binds specifically to the cytoplasmic region of DC-SIGN and directs internalized virus to the proteasome. This cellular protein, leukocyte-specific… CONTINUE READING
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