Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion.

  title={Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion.},
  author={Leslie S Ritter and Karl Matthew Stempel and Bruce M. Coull and P 4 Mariojouls C 9 Muir J F 1 Prothero McDonagh},
  journal={Biological research for nursing},
  volume={6 4},
Ischemic stroke and reperfusion (ISR) is associated with an inflammatory response characterized, in part, by the formation of leukocyte-platelet aggregates (LPA). Aggregate formation may amplify the immunologic and hemostatic functions of both cell types and thus exacerbate reperfusion injury after ischemic stroke. LPA formation in peripheral blood may also serve as a biomarker of the severity of injury. However, it is not fully known whether ISR causes LPA formation that can be detected in the… CONTINUE READING


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