Leukocyte orchestration in blood and tumour tissue following interleukin-2 based immunotherapy in metastatic renal cell carcinoma

@article{Donskov2004LeukocyteOI,
  title={Leukocyte orchestration in blood and tumour tissue following interleukin-2 based immunotherapy in metastatic renal cell carcinoma},
  author={Frede N. Donskov and Karen Marie Bennedsgaard and Marianne Elisabet Hokland and Niels Marcussen and Rune Fisker and Hans Henrik Torp Madsen and Kirsten Fode and Hans von der Maase},
  journal={Cancer Immunology, Immunotherapy},
  year={2004},
  volume={53},
  pages={729-739}
}
With the objective of evaluating leukocyte orchestration in situ, serial blood samples and tumour tissue core needle biopsies were obtained at baseline and repeated after 1 month of therapy, among 49 consecutive single-institution patients with metastatic renal cell carcinoma (mRCC). Patients were treated with outpatient low-dose subcutaneous interleukin 2 (IL-2) and interferon α (IFN-α) alone (n=23) or in combination with histamine dihydrochloride (n=26). Objective responses were achieved in… CONTINUE READING