Leukocyte opioid receptors mediate analgesia via Ca<ce:sup loc=post>2+</ce:sup>-regulated release of opioid peptides

@article{Celik2016LeukocyteOR,
  title={Leukocyte opioid receptors mediate analgesia via Ca<ce:sup loc=post>2+</ce:sup>-regulated release of opioid peptides},
  author={Melih {\"O}zg{\"u}r Celik and Dominika Labuz and Karen Henning and Melanie Busch-Dienstfertig and Halina Machelska},
  journal={Brain, Behavior, and Immunity},
  year={2016},
  volume={57},
  pages={227-242}
}
Opioids are the most powerful analgesics. As pain is driven by sensory transmission and opioid receptors couple to inhibitory G proteins, according to the classical concept, opioids alleviate pain by activating receptors on neurons and blocking the release of excitatory mediators (e.g., substance P). Here we show that analgesia can be mediated by opioid receptors in immune cells. We propose that activation of leukocyte opioid receptors leads to the secretion of opioid peptides Met-enkephalin… CONTINUE READING

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