Leukocyte mimetic polysaccharide microparticles tracked in vivo on activated endothelium and in abdominal aortic aneurysm.

@article{Bonnard2014LeukocyteMP,
  title={Leukocyte mimetic polysaccharide microparticles tracked in vivo on activated endothelium and in abdominal aortic aneurysm.},
  author={Thomas Bonnard and Jean-Michel Serfaty and Cl{\'e}ment Journ{\'e} and Beno{\^i}t Ho Tin Noe and Denis Arnaud and Liliane Louedec and Sidi Mohammed Derkaoui and Didier Letourneur and C{\'e}dric Chauvierre and Catherine Le Visage},
  journal={Acta biomaterialia},
  year={2014},
  volume={10 8},
  pages={3535-45}
}
We have developed injectable microparticles functionalized with fucoidan, in which sulfated groups mimic the anchor sites of P-selectin glycoprotein ligand-1 (PSGL-1), one of the principal receptors supporting leukocyte adhesion. These targeted microparticles were combined with a fluorescent dye and a T2(∗) magnetic resonance imaging (MRI) contrast agent, and then tracked in vivo with small animal imaging methods. Microparticles of 2.5μm were obtained by a water-in-oil emulsification combined… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…