Leukocyte integrin-dependent and antibody-independent cytotoxicity of macrophage against allografts.

@article{Yoshida2000LeukocyteIA,
  title={Leukocyte integrin-dependent and antibody-independent cytotoxicity of macrophage against allografts.},
  author={Ryo Yoshida and Taisuke Oku and Osamu Takikawa and Kuniko Einaga-Naito and Yukio Yoneda and Ryuichi Hirota and Takahiro Kubota},
  journal={Microbiology and immunology},
  year={2000},
  volume={44 1},
  pages={57-67}
}
Macrophages (Mphis), but not T cells, infiltrating into the rejection site of either i.p. allografted Meth A (H-2d) fibrosarcoma cells in C57BL/6 (B6) (H-2b) mice or BALB/c (H-2d) skin onto B6 mice are cytotoxic against allografts with H-2d specificity. To determine the mechanisms of specific killing of allografts by allograft-induced Mphi (AIM), we raised approximately 5,000 rat monoclonal antibodies (mAbs) against AIM and selected three of them (R1-73, R2-40 and R1-34), each of which… CONTINUE READING