Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice.

  title={Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice.},
  author={David Joseph Lefer and Steven P Jones and Wesley G Girod and Amarpreet Baines and Matthew B Grisham and Adam S. Cockrell and Paul Lee Huang and Rosario G Scalia},
  journal={The American journal of physiology},
  volume={276 6 Pt 2},
Nitric oxide (NO) is known to be an important endogenous modulator of leukocyte-endothelial cell interactions within the microcirculation. We examined leukocyte rolling and adhesion under baseline conditions and following thrombin (0.25 U/ml) superfusion in the mesentery of wild-type, inducible NOS (iNOS)-deficient (-/-), neuronal NOS (nNOS) -/-, and endothelial cell NOS (ecNOS) -/- mice to further our understanding of NO and leukocyte function. Baseline leukocyte rolling (cells/min) was… CONTINUE READING


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