Leukocyte-endothelial adherence correlates with pancreatic nitric oxide production in early cerulein-induced pancreatitis in rats.

@article{Chen1998LeukocyteendothelialAC,
  title={Leukocyte-endothelial adherence correlates with pancreatic nitric oxide production in early cerulein-induced pancreatitis in rats.},
  author={Han-Ming Chen and M H Shyr and Y T Lau and T. L. Hwang and Mien-cheng Chen},
  journal={Shock},
  year={1998},
  volume={10 3},
  pages={218-22}
}
The role of nitric oxide (NO) in microcirculation during the development of acute pancreatitis was not clear. An in vivo microscopic technique was used for evaluating leukocyte-endothelial adherence in the pancreatic microcirculation after induction (cerulein) of acute pancreatitis. Microdialysis was performed to detect pancreatic nitrate concentration (NO level) by high-performance liquid chromatography. Cerulein caused significantly reduced flow velocity in 1 h (31 %) and increased the number… CONTINUE READING