Leukocyte emigration in the early stages of laminitis.

  title={Leukocyte emigration in the early stages of laminitis.},
  author={Samuel James Black and David P. Lunn and Cailing Yin and Misako Hwang and Stephen Dana Lenz and J Belknap},
  journal={Veterinary immunology and immunopathology},
  volume={109 1-2},
The mechanisms that initiate the pathophysiologic changes in the digital laminae in equine laminitis are poorly understood. Due to the fact that (1) the horse at risk of laminitis has many similarities clinically to the human sepsis patient and (2) our recent finding of marked laminar proinflammatory cytokine expression at the developmental time point of the black walnut extract (BWE) model of laminitis, we tested the possibility that, similar to organ damage in human sepsis, leukocyte… CONTINUE READING


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