Leukocyte diapedesis and plasma extravasation after leukotriene B4: lack of structural injury to the endothelium.

@article{ThuresonKlein1986LeukocyteDA,
  title={Leukocyte diapedesis and plasma extravasation after leukotriene B4: lack of structural injury to the endothelium.},
  author={A K Thureson-Klein and Per Hedqvist and Lennart Lindbom},
  journal={Tissue & cell},
  year={1986},
  volume={18 1},
  pages={1-12}
}
Leukotriene B4 (LTB4) is a derivative of arachidonic acid which causes neutrophil diapedesis, endothelial swelling and increased permeability of post-capillary venules. To detect whether these effects are accompanied by degranulation of leukocytes and visible injury to the microvessels, the vasculature of rabbit skeletal muscle (tenuissimus) was exposed to LTB4 (10-20 nM). Some preparations were pre-treated with prostaglandin E1, (PGE1). When leukocytes started to adhere markers of plasma… CONTINUE READING

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