Leukocyte depletion attenuates vascular injury in postischemic skeletal muscle.

@article{Korthuis1988LeukocyteDA,
  title={Leukocyte depletion attenuates vascular injury in postischemic skeletal muscle.},
  author={Ronald J. Korthuis and Matthew B Grisham and Dr. D. Neil Granger},
  journal={The American journal of physiology},
  year={1988},
  volume={254 5 Pt 2},
  pages={H823-7}
}
To determine whether leukocytes play an important role in the pathogenesis of the vascular injury (increased vascular permeability and resistance) associated with ischemia-reperfusion, isolated canine gracilis muscles were perfused with autologous whole blood or with whole blood that had been depleted of leukocytes (primarily granulocytes) using Leukopak filters. The osmotic reflection coefficient for total plasma proteins, isogravimetric capillary pressure, and total vascular resistance was… CONTINUE READING

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