Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.

  title={Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.},
  author={David G. Denardo and Donal J Brennan and Elton Rexhepaj and Brian Ruffell and Stephen L. Shiao and Stephen F. Madden and William M. Gallagher and Nikhil Wadhwani and Scott D Keil and Sharfaa A Junaid and Hope S Rugo and E. Shelley Hwang and Karin Jirstr{\"o}m and Brian L West and Lisa M. Coussens},
  journal={Cancer discovery},
  volume={1 1},
UNLABELLED Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance in breast cancer represent prognostic indicators for recurrence-free and overall survival. We provide evidence that response to chemotherapy is in part regulated by these leukocytes; cytotoxic therapies induce mammary epithelial cells to produce monocyte/macrophage recruitment factors, including colony stimulating factor 1… CONTINUE READING
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