Leukocyte and lymphocyte cyclic AMP responses in atopic eczema.

  title={Leukocyte and lymphocyte cyclic AMP responses in atopic eczema.},
  author={C. Woodworth Parker and Simon Kennedy and Arthur Z. Eisen},
  journal={The Journal of investigative dermatology},
  volume={68 5},
Lymphocytes from subjects with mild and severe atopic eczema were compared with normal control subjects in regard to their cAMP (3';5'-cyclic adenosine monophosphate) responses to a variety of stimulatory agents. Individuals in the severe eczema group were shown to have a significant diminution in their unstimulated lymphocyte cAMP levels and absolute cAMP responses to 0.5 mM theophylline, 0.5 mM theophyline + 1 micronM epinephrine, 10 mM isoproternol, 1 mM isoproterenol, 10 mM salbutamol, and… CONTINUE READING

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