Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils

@article{Bainton1987LeukocyteAR,
  title={Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils},
  author={Dorothy Ford Bainton and Lauri J Miller and Takashi Kishimoto and Timothy A Springer},
  journal={The Journal of Experimental Medicine},
  year={1987},
  volume={166},
  pages={1641 - 1653}
}
Previous studies have suggested that the leukocyte adhesion proteins Mac-1 and p150,95 are stored in a latent intracellular pool in neutrophils, and cellular fractionation studies have shown that Mac-1 is localized primarily in the peroxidase-negative specific granules. To determine the subcellular location of leukocyte adhesion receptors (LAR), we used immunocytochemical techniques on frozen thin sections of human blood leukocytes that had been incubated for peroxidase to mark the peroxidase… CONTINUE READING
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