Leukocyte adhesion molecules in animal models of inflammatory bowel disease.

  title={Leukocyte adhesion molecules in animal models of inflammatory bowel disease.},
  author={Jes{\'u}s Rivera-Nieves and Gezahegn Gorfu and Klaus Ley},
  journal={Inflammatory bowel diseases},
  volume={14 12},
The dysregulated recruitment of leukocytes into the intestine is required for the initiation and maintenance of inflammatory bowel disease (IBD). Several families of molecules regulate the influx of these cells into sites of inflammation. Interference with some of these molecules has already shown efficacy in the clinics and antibodies that target the molecules involved have been approved by the FDA for use in Crohn's disease (CD), multiple sclerosis (i.e., natalizumab), and psoriasis (i.e… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 241 references

A randomized , double - masked , placebo - controlled study of alicaforsen , an antisense inhibitor of intercellular adhesion molecule 1 , for the treatment of subjects with active Crohn ’ s disease

  • TG Diacovo, AR deFougerolles, DF Bainton
  • Clin Gastroenterol Hepatol
  • 2007

Critical role of mac - 1 sialyl lewis x moieties in regulating neutrophil degranulation and transmigration

  • GD Ross
  • J Mol Biol
  • 2007

Similar Papers

Loading similar papers…