Leukocyte adhesion molecules in animal models of inflammatory bowel disease.

@article{RiveraNieves2008LeukocyteAM,
  title={Leukocyte adhesion molecules in animal models of inflammatory bowel disease.},
  author={Jes{\'u}s Rivera-Nieves and Gezahegn Gorfu and Klaus Ley},
  journal={Inflammatory bowel diseases},
  year={2008},
  volume={14 12},
  pages={
          1715-35
        }
}
The dysregulated recruitment of leukocytes into the intestine is required for the initiation and maintenance of inflammatory bowel disease (IBD). Several families of molecules regulate the influx of these cells into sites of inflammation. Interference with some of these molecules has already shown efficacy in the clinics and antibodies that target the molecules involved have been approved by the FDA for use in Crohn's disease (CD), multiple sclerosis (i.e., natalizumab), and psoriasis (i.e… CONTINUE READING

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