Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression.

@article{Kong2004LeukocyteAD,
  title={Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression.},
  author={Tianqing Kong and Holger K. Eltzschig and Jorn Karhausen and Sean P Colgan and Carl Simon Shelley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 28},
  pages={
          10440-5
        }
}
Inflammatory responses are associated with significant changes in tissue metabolism. In particular, metabolic shifts during inflammation can result in significant tissue hypoxia, with resultant induction of hypoxia-responsive genes. Given this association, we hypothesized that leukocyte functional responses are influenced by hypoxia. Initial experiments revealed that exposure of the promonocytic cell line U937 to hypoxia resulted in increased adhesion to activated endothelia. Such increases… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 121 CITATIONS, ESTIMATED Infinity% COVERAGE

121 Citations

0510'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 121 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…