Leukocyte adhesion deficiency type II.

@article{Becker1999LeukocyteAD,
  title={Leukocyte adhesion deficiency type II.},
  author={Daniel J Becker and John B. Lowe},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1455 2-3},
  pages={193-204}
}
Leukocyte adhesion deficiency type II (LAD II) is a rare disorder characterized by recurrent infections, persistent leukocytosis, and severe mental and growth retardation. LAD II neutrophils are deficient in expression of selectin ligand activity, and exhibit a correspondingly diminished ability to roll on endothelium and to traffic to inflammatory sites in vivo. LAD II patients exhibit a deficiency in the expression of cell surface fucosylated glycan structures that include the H and Lewis… CONTINUE READING

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