• Medicine, Biology
  • Published in Immunodeficiency reviews 1988

Leukocyte adhesion deficiency: molecular basis and functional consequences.

@article{Fischer1988LeukocyteAD,
  title={Leukocyte adhesion deficiency: molecular basis and functional consequences.},
  author={Alain Fischer and Barbara Lisowska-Grospierre and Donald C. Anderson and Timothy A Springer},
  journal={Immunodeficiency reviews},
  year={1988},
  volume={1 1},
  pages={
          39-54
        }
}
Leukocyte adhesion deficiency disease is characterized by a mutation in the gene encoding the beta-subunit shared by three adhesive heterodimers, LFA-1, Mac-1 (CR3) and p150,95 expressed by leukocytes. An absent or abnormal beta-subunit leads to defective expression of the three heterodimers. Severe and moderate phenotypes of the disease are defined by absent and low surface expression of the adhesion molecules. The disease causes an inability of phagocytic cells to adhere to endothelial cells… CONTINUE READING

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