Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

@article{Palabrica1992LeukocyteAP,
  title={Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets},
  author={Theresa M. Palabrica and Laurelee Osborn and Bruce Furie and Mark A. Aronovitz and Christopher D. Benjamin and Yen-Ming Hsu and Susan A. Sajer},
  journal={Nature},
  year={1992},
  volume={359},
  pages={848-851}
}
THE glycoprotein P-selectin is a cell adhesion molecule of stimulated platelets and endothelial cells, which mediates the interaction of these cells with neutrophils and monocytes1,2. It is a membrane component of cell storage granules3–6, and is a member of the selectin family which includes E-selectin and L-selectin7,8. P-selectin recognizes both lineage-specific carbohydrate ligands on monocytes and neutrophils, including the Lewis x antigen, sialic acid, and a protein component9–12. In… CONTINUE READING
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