Leukocyte Telomere Length in HIV-Infected and HIV-Exposed Uninfected Children: Shorter Telomeres with Uncontrolled HIV Viremia

@inproceedings{Ct2012LeukocyteTL,
  title={Leukocyte Telomere Length in HIV-Infected and HIV-Exposed Uninfected Children: Shorter Telomeres with Uncontrolled HIV Viremia},
  author={H{\'e}l{\`e}ne C F C{\^o}t{\'e} and Hugo Soudeyns and Anona Elaine Thorne and Ariane Alimenti and Val{\'e}rie Lamarre and Evelyn J Maan and Beheroze Sattha and Joel Singer and Normand D Lapointe and Deborah M Money and John C. Forbes},
  booktitle={PloS one},
  year={2012}
}
OBJECTIVES Nucleoside reverse transcriptase inhibitors (NRTIs) used in HIV antiretroviral therapy can inhibit human telomerase reverse transcriptase. We therefore investigated whether in utero or childhood exposure to NRTIs affects leukocyte telomere length (LTL), a marker of cellular aging. METHODS In this cross-sectional CARMA cohort study, we investigated factors associated with LTL in HIV-1-infected (HIV(+)) children (n = 94), HIV-1-exposed uninfected (HEU) children who were exposed to… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

Telomere length as a putative biomarker of health and disease

VIEW 7 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Abnormal Bone Acquisition With Early-Life HIV Infection: Role of Immune Activation and Senescent Osteogenic Precursors.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2016

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

In vitro and in vivo inhibition studies of human telomerase by HIV reverse transcriptase

KC Hukazelie, J Wong
  • HEU and HIV2 Children PLoS ONE | www.plosone.org
  • 2011
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…