Leukemogenesis of adult T-cell leukemia.

  title={Leukemogenesis of adult T-cell leukemia.},
  author={Jun-Ichirou Yasunaga and Masao Matsuoka},
  journal={International journal of hematology},
  volume={78 4},
Adult T-cell leukemia (ATL) is one of the most aggressive hematologic malignancies and is caused by human T-cell leukemia virus type I (HTLV-I). Tax, encoded by the HTLV-I pX region, has been recognized by its pleiotropic actions as a critical accessory protein playing a central role in leukemogenesis. However, fresh ATL cells frequently lose Tax protein expression via several mechanisms, such as genetic and epigenetic changes in the provirus. Furthermore, there is a long latency period before… CONTINUE READING