Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium

@article{Miller2005LeukemicTO,
  title={Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium},
  author={Alexandra C Miller and Catherine Bonait-Pellie and Robert F. Merlot and Jan Michel and Michael Stewart and Paul D. Lison},
  journal={Molecular and Cellular Biochemistry},
  year={2005},
  volume={279},
  pages={97-104}
}
Depleted uranium (DU) is a dense heavy metal used in military applications. During military conflicts, US military personnel have been wounded by DU shrapnel. The health effects of embedded DU are unknown. Published data from our laboratory demonstrated that DU exposure in vitro can transform immortalized human osteoblast cells (HOS) to the tumorigenic phenotype. Results from our laboratory have also shown that DU is genotoxic and mutagenic in cultured human cells. Internalized DU could be a… Expand
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