Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.

@article{Qiu2010LeukemicTB,
  title={Leukemic transformation by the APL fusion protein PRKAR1A-RAR\{alpha\} critically depends on recruitment of RXR\{alpha\}.},
  author={Jihui Julia Qiu and Xiaoxi Lu and Bernd B. Zeisig and Zhigui Ma and Xun Cai and Sai-juan Chen and Hinrich Gronemeyer and David J Tweardy and Chi Wai Eric So and Shuo Dong},
  journal={Blood},
  year={2010},
  volume={115 3},
  pages={643-52}
}
PRKAR1A (R1A)-retinoic acid receptor-alpha (R1A-RARalpha) is the sixth RARalpha-containing fusion protein in acute promyelocytic leukemia (APL). Using the murine bone-marrow retroviral transduction/transformation assay, we showed that R1A-RARalpha fusion protein could transform bone-marrow progenitor/stem cells. In gel-shift assays, R1A-RARalpha was able to bind to a panel of retinoic acid response elements both as a homodimer and as a heterodimer with RXRalpha, and demonstrated distinct DNA… CONTINUE READING