Leukemic progression as process of adaptation (theoretical model).

  • I V Alekseyev
  • Published 1992 in Medical oncology and tumor pharmacotherapy


On the basis of an assumption that leukemic progression is a process of adaptation of normal hemopoiesis to the effect of the leukemic clone, a theoretical model of leukemia development is built. General conclusions are as follows: the possibility of reaching remission depends upon suppression of normal hemopoiesis by cytostatics in a system of two cell… (More)