Leukemic cells and the cytokine patchwork.

  title={Leukemic cells and the cytokine patchwork.},
  author={Csongor Kiss and Ilona Benkő and Peter Kovacs},
  journal={Pediatric blood & cancer},
  volume={42 2},
BACKGROUND In leukemia, the clonal population is characterized by a hierarchical organization. Although the majority of the leukemic population is generated after post-determinic divisions, a subset of cells retain undifferentiated "blast" morphology. In addition, leukemic cells often have numerical or structural chromosomal abnormalities, aberrant gene expression patterns, and abnormal cell surface marker profiles. Despite these differences when compared to normal bone marrow and blood cells… CONTINUE READING