Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.

@article{Mishima2002LeukemicCC,
  title={Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.},
  author={Yuji Mishima and Yuko Matsumoto-Mishima and Yasuhito Terui and Misa Katsuyama and Muneo Yamada and Masaki Mori and Yukihito Ishizaka and Kazuma Ikeda and Jun-ichiro Watanabe and Nobuyuki Mizunuma and Hirotoshi Hayasawa and Kiyohiko Hatake},
  journal={Journal of the National Cancer Institute},
  year={2002},
  volume={94 13},
  pages={1020-8}
}
BACKGROUND Attachment of leukemic cells to vascular endothelial cells induces the vascular endothelial cells to release endothelial cell-derived interleukin 8 (endothelial IL-8), which then induces leukemic cells to undergo apoptosis. NB4, a human promyelocytic leukemic cell line that expresses high levels of cell-surface CD13/aminopeptidase N, does not undergo endothelial IL-8-induced apoptosis. Consequently, we investigated the relationship between cell-surface aminopeptidase activity and… CONTINUE READING