Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.

@article{Mishima2002LeukemicCC,
  title={Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.},
  author={Y. Mishima and Y. Matsumoto-Mishima and Y. Terui and Misa Katsuyama and Muneo Yamada and M. Mori and Y. Ishizaka and K. Ikeda and J. Watanabe and N. Mizunuma and H. Hayasawa and K. Hatake},
  journal={Journal of the National Cancer Institute},
  year={2002},
  volume={94 13},
  pages={
          1020-8
        }
}
  • Y. Mishima, Y. Matsumoto-Mishima, +9 authors K. Hatake
  • Published 2002
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • BACKGROUND Attachment of leukemic cells to vascular endothelial cells induces the vascular endothelial cells to release endothelial cell-derived interleukin 8 (endothelial IL-8), which then induces leukemic cells to undergo apoptosis. NB4, a human promyelocytic leukemic cell line that expresses high levels of cell-surface CD13/aminopeptidase N, does not undergo endothelial IL-8-induced apoptosis. Consequently, we investigated the relationship between cell-surface aminopeptidase activity and… CONTINUE READING
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