Leukemic cell products down-regulate human dendritic cell differentiation

  title={Leukemic cell products down-regulate human dendritic cell differentiation},
  author={Juliana Maria Motta and Clarissa Rodrigues Nascimento and Vivian M. Rumjanek},
  journal={Cancer Immunology, Immunotherapy},
The microenvironment produced by solid tumors is inhibitory to the immune system, inducing dendritic cell (DC) alterations, but there is a paucity of information regarding haematological malignances. The aim of this study was to investigate DC differentiation under the influence of leukemic cell products. Monocytes from healthy volunteers were cultured in the presence of IL-4 and GM-CSF for the generation of immature DCs. Supernatants from leukemic cultures were added to monocyte cultures… CONTINUE READING