Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

  title={Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.},
  author={Manar S Shafat and Thomas Oellerich and Sebastian Mohr and Stephen D Robinson and Dylan R W Edwards and Christopher R. Marlein and Rachel E. Piddock and Matthew E. Fenech and Lyubov Zaitseva and Amina M Abdul-Aziz and Jeremy J. O. Turner and Johnathan Watkins and Matthew J. Lawes and Kristian M Bowles and Stuart A. Rushworth},
  volume={129 10},
Despite currently available therapies, most patients diagnosed with acute myeloid leukemia (AML) die of their disease. Tumor-host interactions are critical for the survival and proliferation of cancer cells; accordingly, we hypothesize that specific targeting of the tumor microenvironment may constitute an alternative or additional strategy to conventional tumor-directed chemotherapy. Because adipocytes have been shown to promote breast and prostate cancer proliferation, and because the bone… CONTINUE READING
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