Leukemic Stem Cell Frequency: A Strong Biomarker for Clinical Outcome in Acute Myeloid Leukemia

@inproceedings{Terwijn2014LeukemicSC,
  title={Leukemic Stem Cell Frequency: A Strong Biomarker for Clinical Outcome in Acute Myeloid Leukemia},
  author={Monique Terwijn and Wendelien Zeijlemaker and Ang{\`e}le Kelder and Arjo P. Rutten and Alexander N. Snel and Willemijn J. Scholten and Thomas Pabst and Gregor E. G. Verhoef and Bob L{\"o}wenberg and Sonja Zweegman and Gert Jan Ossenkoppele and Gerrit J Schuurhuis and Kevin D. Bunting},
  booktitle={PloS one},
  year={2014}
}
INTRODUCTION Treatment failure in acute myeloid leukemia is probably caused by the presence of leukemia initiating cells, also referred to as leukemic stem cells, at diagnosis and their persistence after therapy. Specific identification of leukemia stem cells and their discrimination from normal hematopoietic stem cells would greatly contribute to risk stratification and could predict possible relapses. RESULTS For identification of leukemic stem cells, we developed flow cytometric methods… CONTINUE READING
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