Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

@article{Modlich2005LeukemiasFR,
  title={Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.},
  author={Ute Modlich and Olga S. Kustikova and Manfred Dipl.-Phys. Schmidt and Cornelia Rudolph and Johann Conrad Meyer and Zhixiong Li and Kenji Kamino and Nils von Neuhoff and Brigitte Schlegelberger and Klaus Kuehlcke and Kevin D. Bunting and Sonja L. Gary Schmidt and Angelika Deichmann and Christof von Kalle and Boris Fehse and Christopher C. Baum},
  journal={Blood},
  year={2005},
  volume={105 11},
  pages={
          4235-46
        }
}
Previous studies have demonstrated leukemic complications in mice after high-copy retroviral gene transfer of the multidrug resistance 1 (MDR1) cDNA, encoding a membrane-located efflux pump expressed in hematopoietic stem cells. In contrast, no such complications or MDR1-associated alterations of hematopoiesis were observed in numerous other studies exploring MDR1 gene transfer into cell lines, mice, dogs, nonhuman primates, and human subjects. Here, we show that leukemias associated with… CONTINUE READING

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