Leukemia stem cells in 2010: current understanding and future directions.


Myeloid leukemias are clonal disorders originating in a primitive multipotential hematopoietic cell and characterized by aberrant proliferation, differentiation and maturation of leukemic progenitors and precursor cells. These diseases are the result of multiple genetic and epigenetic events, although the nature and number of events vary widely among… (More)
DOI: 10.1016/j.blre.2010.11.001