Leukemia stem cells and microenvironment: biology and therapeutic targeting.


Acute myelogenous leukemia is propagated by a subpopulation of leukemia stem cells (LSCs). In this article, we review both the intrinsic and extrinsic components that are known to influence the survival of human LSCs. The intrinsic factors encompass regulators of cell cycle and prosurvival pathways (such as nuclear factor kappa B [NF-κB], AKT), pathways… (More)
DOI: 10.1200/JCO.2010.31.0904