Leukemia stem cells and microenvironment: biology and therapeutic targeting.

@article{Konopleva2011LeukemiaSC,
  title={Leukemia stem cells and microenvironment: biology and therapeutic targeting.},
  author={Marina Y Konopleva and Craig T. Jordan},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 5},
  pages={591-9}
}
Acute myelogenous leukemia is propagated by a subpopulation of leukemia stem cells (LSCs). In this article, we review both the intrinsic and extrinsic components that are known to influence the survival of human LSCs. The intrinsic factors encompass regulators of cell cycle and prosurvival pathways (such as nuclear factor kappa B [NF-κB], AKT), pathways regulating oxidative stress, and specific molecular components promoting self-renewal. The extrinsic components are generated by the bone… CONTINUE READING