Leukemia propagating cells rebuild an evolving niche in response to therapy.

@article{Duan2014LeukemiaPC,
  title={Leukemia propagating cells rebuild an evolving niche in response to therapy.},
  author={Cai-wen Duan and Jun Shi and Jing Chen and Bo Wang and Ye-Hua Yu and Xia ng Qin and Xiang-Cheng Zhou and Yi-Jun Cai and Zuo-Qing Li and F. W. Zhang and Min-zhi Yin and Ying chu Tao and Jian-Qing Mi and Lin-Heng Li and Tariq Enver and Guoqiang Jerry Chen and Dengli Hong},
  journal={Cancer cell},
  year={2014},
  volume={25 6},
  pages={
          778-93
        }
}
Residence of cancer-propagating cells (CPCs) within preferential microenvironmental niches has a major part in evading therapy. However, the nature of niches involved and the mechanisms protecting CPCs remain largely unknown. We addressed these issues in mouse transplantation models of acute lymphoblastic leukemia (ALL). When the engrafted leukemic cells substantially damaged adjacent microenvironment in the bone marrow (BM), after chemotherapy small foci of CPCs were retained, surrounded by… CONTINUE READING
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