Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance.

@article{Liu2013LeukemiaIF,
  title={Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance.},
  author={Shu-chen Liu and Ngan-Ming Tsang and Wen-Che Chiang and Kuming Chang and Chuen Hsueh and Ying Liang and J-C. Juang and Kai-ping Chow and Yu-sun Chang},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 12},
  pages={
          5269-83
        }
}
Radioresistance of EBV-associated nasopharyngeal carcinoma (NPC) is associated with poor prognosis for patients with this form of cancer. Here, we found that NPC patients had increased serum levels of leukemia inhibitory factor (LIF) and that higher LIF levels correlated with local tumor recurrence. Furthermore, in vitro studies with NPC cells and in vivo xenograft mouse studies demonstrated that LIF critically contributes to NPC tumor growth and radioresistance. Using these model systems, we… CONTINUE READING

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