Leukemia inhibitory factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells.

@article{Setati2009LeukemiaIF,
  title={Leukemia inhibitory factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells.},
  author={Mokgadi M Setati and Earl Prinsloo and Victoria Mary Longshaw and Patricia Alison Murray and David H. Edgar and Gregory L Blatch},
  journal={IUBMB life},
  year={2009},
  volume={62 1},
  pages={
          61-6
        }
}
Self-renewal of in vitro cultured mouse embryonic stem (mES) cells is dependent on the presence of leukemia inhibitory factor (LIF). LIF induces overexpression and tyrosine phosphorylation of STAT3 (signal transducer and activator of transcription 3) and its subsequent nuclear translocation. The molecular chaperone heat shock protein 90 (Hsp90) is involved in the activation and maturation of a wide variety of substrate proteins. We investigated the effect of LIF withdrawal on the protein… CONTINUE READING
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