Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: its possible implication during pregnancy, including implantation period.

@article{Sawai1995LeukemiaIF,
  title={Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: its possible implication during pregnancy, including implantation period.},
  author={Ken Sawai and Nobue Matsuzaki and Takashi Kameda and Kenichiro Hashimoto and Takayoshi Okada and Kouichirou Shimoya and T Nobunaga and Tetsuya Taga and Takeo Kishimoto and Fumitaka Saji},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 4},
  pages={1449-56}
}
We investigated the role of leukemia inhibitory factor (LIF) at the implantation site of human embryos. The first trimester decidual tissue produced higher levels of LIF than chorionic tissue, but the decidua produced much smaller amounts of interleukin-6 (IL-6) than the chorion in vitro, as determined by enzyme-linked immunosorbent assay. The reverse transcription-polymerase chain reaction and immunohistochemical analysis revealed the expression and localization, on the trophoblasts, of… CONTINUE READING